Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.49 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL577459 | 0.80 | PTGS2 (0.54) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL577022 | 0.80 | PTGS2 (0.45) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL7131340 | 0.76 | PTGS2 (0.67) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL585080 | 0.75 | CXCL8 (0.48) | PTGS2PTGS1ABCB11NR1I3CXCL8 | |
| SCHEMBL27595572 | 0.73 | PTGS2 (0.64) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL576775 | 0.73 | PTGS2 (0.65) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL586377 | 0.70 | CXCL8 (0.47) | PTGS2PTGS1ABCB11NR1I3CXCL8 | |
| SCHEMBL7129516 | 0.69 | PTGS2 (0.53) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL7122501 | 0.69 | PTGS2 (0.64) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| Lumiracoxib SCHEMBL4479 | 0.67 | PTGS2 (1.00) | PTGS2PTGS1ABCB11PPARGNR1I3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418200-A1 | PHTHALIMIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND/OR TNF- MODULATORS, METHOD FOR PRODUCING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF FOR THE TREATMENT OF INFLAMMATORY DISEASES | EMS S. A. (BR) | 2012-02-15 | — | — | EP | claimed |