Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 15/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 14/20 | 0.53 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.52 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | PLD2 | O14939 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863925 | 0.86 | EPHX2 (0.49) | EPHX2ESR1ESR2PSMB1PSMB5 | |
| SCHEMBL5863807 | 0.86 | ESR1 (0.57) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL5863955 | 0.83 | LTA4H (0.57) | ESR1ESR2KDRHRH3PTGS2 | |
| SCHEMBL5864316 | 0.82 | PSMB1 (0.59) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| Hydrochloric Acid SCHEMBL5863873 | 0.81 | PSMB1 (0.57) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL5863974 | 0.81 | KDR (0.59) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL5863736 | 0.81 | EPHX2 (0.46) | EPHX2ESR1ESR2PSMB1PSMB5 | |
| Trifluoroacetic Acid SCHEMBL5863930 | 0.79 | HRH3 (0.51) | ESR1ESR2KDRHRH3 | |
| SCHEMBL5864234 | 0.79 | EPHX2 (0.43) | EPHX2LMNADRD2HRH2DRD3 | |
| SCHEMBL14287743 | 0.76 | GLA (0.74) | PSMB1PSMB5PSMB2ALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053212-B2 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | GHSR, GPER1, SSTR1 | EPHX2 1166/4885ESR1 4/4885ESR2 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.