Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864181 | 0.92 | ESR1 (0.46) | ESR1ESR2KCNH2MCHR1LTA4H | |
| SCHEMBL5863563 | 0.92 | LTA4H (0.48) | ESR1ESR2KCNH2MCHR1LTA4H | |
| SCHEMBL5863859 | 0.91 | ESR1 (0.50) | ESR1ESR2KCNH2MCHR1LTA4H | |
| SCHEMBL5864229 | 0.90 | LTA4H (0.45) | ESR1ESR2KCNH2MCHR1LTA4H | |
| SCHEMBL5863836 | 0.90 | LTA4H (0.46) | ESR1ESR2KCNH2MCHR1LTA4H | |
| SCHEMBL5863720 | 0.89 | NR3C1 (0.44) | ESR1ESR2LTA4HHTTMET | |
| SCHEMBL5863330 | 0.88 | LTA4H (0.43) | ESR1ESR2KCNH2MCHR1LTA4H | |
| SCHEMBL5863643 | 0.87 | ESR1 (0.49) | ESR1ESR2LTA4H | |
| SCHEMBL5863843 | 0.87 | NR3C1 (0.50) | ESR1ESR2KCNH2MCHR1LTA4H | |
| SCHEMBL5864023 | 0.87 | HTT (0.47) | ESR1ESR2KCNH2MCHR1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053212-B2 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | GHSR, GPER1, SSTR1 | ESR1 4/4885ESR2 12/4885KCNH2 1736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.