Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29363229 | 0.84 | MEN1 (0.64) | LTA4HMAPK14RAB9ANPC1MEN1 | |
| SCHEMBL14909268 | 0.82 | NPC1 (0.51) | LTA4HMAPK14RAB9ANPC1MEN1 | |
| SCHEMBL29360828 | 0.80 | NPC1 (0.77) | LTA4HMAPK14RAB9ANPC1MEN1 | |
| SCHEMBL1101199 | 0.80 | NPC1 (0.77) | LTA4HMAPK14RAB9ANPC1MEN1 | |
| Hydrochloric Acid SCHEMBL4754679 | 0.78 | NPC1 (0.74) | LTA4HMAPK14RAB9ANPC1MEN1 | |
| SCHEMBL12154961 | 0.78 | MRGPRX4 (0.48) | LTA4HMAPK14RAB9ANPC1CYP19A1 | |
| SCHEMBL6670845 | 0.77 | MEN1 (0.50) | LTA4HMAPK14RAB9ANPC1MEN1 | |
| SCHEMBL5865429 | 0.77 | MAPT (0.71) | RAB9ANPC1MEN1KMT2ACYP19A1 | |
| SCHEMBL5330815 | 0.77 | CYP3A4 (0.55) | LTA4HMAPK14RAB9ANPC1MEN1 | |
| SCHEMBL6027354 | 0.77 | NPC1 (0.62) | LTA4HMAPK14RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7064117-B2 | Anti-cancer 2,3-dihydro-1H-pyrrolo[3,2-f]quinoline complexes of cobalt and chromium | AUCKLAND UNISERVICES LIMITED (NZ) | 2006-06-20 | — | — | US | disclosed |
| US-20050038249-A1 | Anti-cancer 2,3-dihydro-1H-pyrrole[3,2-f] quinoline compolexes of cobalt and chromium | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-02-17 | — | — | US | disclosed |
| US-20040138195-A1 | Anti-cancer 2,3-dihydro-1h-pyrrolo[3,2-f[quinoline complexes of cobalt and chromium | AUCKLAND UNISERVICES LIMITED (NZ) | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138195-A1 | Anti-cancer 2,3-dihydro-1h-pyrrolo[3,2-f[quinoline complexes of cobalt and chromium | IDH1, HIF1AN, CA2 | LTA4H 4124/4885MAPK14 3898/4885RAB9A 3664/4885 |
| US-20050038249-A1 | Anti-cancer 2,3-dihydro-1H-pyrrole[3,2-f] quinoline compolexes of cobalt and chromium | CA2, HIF1AN, PPOX | LTA4H 4089/4885MAPK14 4372/4885RAB9A 3618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.