Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5865588 | 0.89 | CYP3A4 (0.53) | CYP3A4TSHRMAPK1ATML3MBTL1 | |
| SCHEMBL5865578 | 0.89 | MAPT (0.46) | CYP3A4TSHRMAPK1ATML3MBTL1 | |
| SCHEMBL5865560 | 0.85 | CYP3A4 (0.57) | CYP3A4TSHRMAPK1ATML3MBTL1 | |
| SCHEMBL5865618 | 0.82 | CYP3A4 (0.57) | CYP3A4TSHRMAPK1ATML3MBTL1 | |
| SCHEMBL5865640 | 0.79 | NPFFR2 (0.44) | CYP3A4TSHRMAPK1ATML3MBTL1 | |
| SCHEMBL12097542 | 0.78 | MAPT (0.54) | MAPK1TMPRSS4MAPTNPSR1XBP1 | |
| SCHEMBL5865631 | 0.77 | NOTUM (0.53) | CYP3A4TSHRMAPK1ATML3MBTL1 | |
| SCHEMBL31193921 | 0.77 | TMPRSS4 (0.51) | CYP3A4TSHRMAPK1L3MBTL1TMPRSS4 | |
| SCHEMBL1410268 | 0.77 | TMPRSS4 (0.51) | CYP3A4TSHRMAPK1L3MBTL1TMPRSS4 | |
| SCHEMBL5865501 | 0.76 | CYP3A4 (0.40) | CYP3A4TSHRMAPK1ATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091248-B2 | Treatment of adrenocortical hypersecretion and tumor growth | BRANDT INGVAR | 2006-08-15 | — | — | US | disclosed |
| US-20040242705-A1 | Novel treatment of adrenocortical hypersecretion and tumour growth | BRANDT INGVAR (SE) | 2004-12-02 | — | — | US | disclosed |
| EP-1412311-A1 | NOVEL TREATMENT OF ADRENOCORTICAL HYPERSECRETION AND TUMOUR GROWTH | Brandt, Ingvar (SE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003002495-A1 | NOVEL TREATMENT OF ADRENOCORTICAL HYPERSECRETION AND TUMOUR GROWTH | BRANDT INGVAR (SE) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242705-A1 | Novel treatment of adrenocortical hypersecretion and tumour growth | NR3C2, NR5A1, NR3C1 | CYP3A4 519/4885TSHR 118/4885MAPK1 2454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.