Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5865501 | 0.88 | CYP3A4 (0.40) | KDRLMNATP53MAPTTHRB | |
| SCHEMBL5865578 | 0.87 | MAPT (0.46) | LMNAMAPTCYP3A4TSHRMAPK1 | |
| SCHEMBL5865560 | 0.87 | CYP3A4 (0.57) | NPFFR2KDRLMNATP53MAPT | |
| SCHEMBL5865631 | 0.83 | NOTUM (0.53) | LMNAMAPTCYP3A4TSHRMAPK1 | |
| SCHEMBL5865199 | 0.79 | CYP3A4 (0.55) | LMNAMAPTCYP3A4TSHRMAPK1 | |
| SCHEMBL1794695 | 0.76 | KDR (0.54) | NPFFR2KDRLMNAMAPTHTR3E | |
| SCHEMBL31542016 | 0.76 | KDR (0.54) | NPFFR2KDRLMNAMAPTHTR3E | |
| SCHEMBL264729 | 0.75 | IDO1 (0.47) | NPFFR2KDRLMNATP53MAPT | |
| SCHEMBL29707579 | 0.75 | IDO1 (0.47) | NPFFR2KDRLMNATP53MAPT | |
| SCHEMBL9494805 | 0.75 | TSHR (0.59) | LMNAMAPTCYP3A4TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091248-B2 | Treatment of adrenocortical hypersecretion and tumor growth | BRANDT INGVAR | 2006-08-15 | — | — | US | disclosed |
| US-20040242705-A1 | Novel treatment of adrenocortical hypersecretion and tumour growth | BRANDT INGVAR (SE) | 2004-12-02 | — | — | US | disclosed |
| EP-1412311-A1 | NOVEL TREATMENT OF ADRENOCORTICAL HYPERSECRETION AND TUMOUR GROWTH | Brandt, Ingvar (SE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003002495-A1 | NOVEL TREATMENT OF ADRENOCORTICAL HYPERSECRETION AND TUMOUR GROWTH | BRANDT INGVAR (SE) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242705-A1 | Novel treatment of adrenocortical hypersecretion and tumour growth | NR3C2, NR5A1, NR3C1 | NPFFR2 332/4885KDR 295/4885LMNA 4842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.