Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 13/20 | 0.47 |
| ▸ | FLT1 | P17948 | 10/20 | 0.47 |
| ▸ | BCR | P11274 | 2/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5866701 | 0.89 | FGFR1 (0.60) | ABL1FGFR1FLT1BCRUSP30 | |
| SCHEMBL5866910 | 0.89 | FGFR1 (0.42) | ABL1FGFR1FLT1ITKCDK4 | |
| SCHEMBL5866690 | 0.86 | FGFR1 (0.40) | ABL1FGFR1FLT1CDK4CCNA2 | |
| SCHEMBL5866660 | 0.86 | FGFR1 (0.60) | ABL1FGFR1FLT1BCRCDK4 | |
| SCHEMBL3537724 | 0.79 | FGFR1 (0.65) | ABL1FGFR1FLT1BCRCDK4 | |
| SCHEMBL5866685 | 0.78 | FGFR1 (0.44) | ABL1FGFR1FLT1CDK4CCNA2 | |
| SCHEMBL3538556 | 0.78 | ABL1 (0.39) | ABL1FGFR1FLT1BCRITK | |
| SCHEMBL3595759 | 0.76 | FGFR1 (0.38) | ABL1FGFR1FLT1BCR | |
| SCHEMBL3542676 | 0.76 | FGFR1 (0.48) | ABL1FGFR1FLT1ITKCDK2 | |
| SCHEMBL5866803 | 0.76 | ABL1 (0.49) | ABL1FGFR1FLT1CDK4CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7064215-B2 | Indazole benzimidazole compounds | CHIRON CORPORATION (US) | 2006-06-20 | — | — | US | disclosed |