Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.42 |
| ▸ | FLT1 | P17948 | 7/20 | 0.42 |
| ▸ | ABL1 | P00519 | 7/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CCND1 | P24385 | 2/20 | 0.40 |
| ▸ | CCND3 | P30281 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5866690 | 0.91 | FGFR1 (0.40) | FGFR1FLT1ABL1CDK2CDK4 | |
| SCHEMBL5866718 | 0.89 | ABL1 (0.47) | FGFR1FLT1ABL1CDK2CDK4 | |
| SCHEMBL5866685 | 0.88 | FGFR1 (0.44) | FGFR1FLT1ABL1CDK2CDK4 | |
| SCHEMBL5866803 | 0.83 | ABL1 (0.49) | FGFR1FLT1ABL1CDK2CDK4 | |
| SCHEMBL5866802 | 0.80 | ABL1 (0.39) | FGFR1FLT1ABL1CDK2CDK4 | |
| SCHEMBL3542676 | 0.79 | FGFR1 (0.48) | FGFR1FLT1ABL1CDK2CHEK1 | |
| SCHEMBL5866701 | 0.78 | FGFR1 (0.60) | FGFR1FLT1ABL1PDPK1 | |
| SCHEMBL5866777 | 0.78 | FGFR1 (0.46) | FGFR1FLT1ABL1CDK2CDK4 | |
| SCHEMBL3539088 | 0.77 | FGFR1 (0.39) | FGFR1FLT1ABL1CDK2CDK4 | |
| SCHEMBL5866660 | 0.77 | FGFR1 (0.60) | FGFR1FLT1ABL1CDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7064215-B2 | Indazole benzimidazole compounds | CHIRON CORPORATION (US) | 2006-06-20 | — | — | US | disclosed |