Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 4/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3534641 | 0.92 | PDPK1 (0.43) | ITKABL1PDPK1MAPTSMN1; SMN2 | |
| SCHEMBL6582455 | 0.88 | ABL1 (0.53) | ABL1FLT3FGFR1FLT1BCR | |
| SCHEMBL5866736 | 0.87 | PDPK1 (0.39) | ABL1PDPK1MAPTSMN1; SMN2CHEK2 | |
| SCHEMBL3533655 | 0.87 | MAPT (0.43) | ITKABL1PDPK1MAPTSMN1; SMN2 | |
| SCHEMBL5866637 | 0.86 | TTK (0.43) | ABL1PDPK1FLT3FGFR1FLT1 | |
| SCHEMBL5866728 | 0.83 | ABL1 (0.51) | ABL1FGFR1FLT1KDR | |
| SCHEMBL5866631 | 0.83 | ABL1 (0.51) | ABL1FGFR1FLT1KDR | |
| SCHEMBL5866636 | 0.83 | ABL1 (0.51) | ABL1FGFR1FLT1KDR | |
| SCHEMBL3532328 | 0.83 | PDPK1 (0.52) | ABL1PDPK1FLT3FGFR1FLT1 | |
| SCHEMBL5866643 | 0.83 | ABL1 (0.51) | ABL1FGFR1FLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7064215-B2 | Indazole benzimidazole compounds | CHIRON CORPORATION (US) | 2006-06-20 | — | — | US | disclosed |