Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 14/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 14/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | NOS2 | P35228 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GPR183 | P32249 | 1/20 | 0.50 |
| ▸ | APLNR | P35414 | 1/20 | 0.50 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.50 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869187 | 1.00 | SLC6A4 (0.70) | SLC6A4SLC6A2CYP2D6NOS2MEN1 | |
| SCHEMBL5869188 | 0.90 | SLC6A4 (0.69) | SLC6A4SLC6A2CYP2D6NOS2MEN1 | |
| SCHEMBL5869192 | 0.90 | SLC6A4 (0.69) | SLC6A4SLC6A2CYP2D6NOS2MEN1 | |
| SCHEMBL5869252 | 0.87 | SLC6A4 (0.54) | SLC6A4SLC6A2CYP2D6KMT2APMP22 | |
| SCHEMBL5869251 | 0.87 | SLC6A4 (0.54) | SLC6A4SLC6A2CYP2D6KMT2APMP22 | |
| SCHEMBL5869278 | 0.86 | SLC6A2 (0.68) | SLC6A4SLC6A2CYP2D6MEN1LMNA | |
| SCHEMBL5869283 | 0.86 | SLC6A2 (0.68) | SLC6A4SLC6A2CYP2D6MEN1LMNA | |
| SCHEMBL5869148 | 0.84 | SLC6A2 (0.69) | SLC6A4SLC6A2CYP2D6NOS2MEN1 | |
| SCHEMBL5869145 | 0.84 | SLC6A2 (0.69) | SLC6A4SLC6A2CYP2D6NOS2MEN1 | |
| SCHEMBL5869354 | 0.83 | SLC6A4 (0.67) | SLC6A4SLC6A2CYP2D6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037932-B2 | Heteroaryloxy 3-substituted propanamines as serotonin and norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY (US) | 2006-05-02 | — | — | US | disclosed |
| US-20040176435-A1 | Heteroaryloxy 3-substituted propanamines s serotonin and norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176435-A1 | Heteroaryloxy 3-substituted propanamines s serotonin and norepinephrine reuptake inhibitors | ADRA2C, ADRB1, TPH1 | SLC6A4 7/4885SLC6A2 5/4885CYP2D6 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.