Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1820197 | 1.00 | F2 (0.47) | F2ELANECTSGPSEN1PSEN2 | |
| SCHEMBL28956472 | 0.85 | PSEN1 (0.48) | F2ELANECTSGPSEN1PSEN2 | |
| SCHEMBL14897525 | 0.83 | RAB9A (0.40) | RAB9ASMN1; SMN2 | |
| SCHEMBL6822684 | 0.80 | GAA (0.40) | ELANEMEN1KMT2AUSP2 | |
| SCHEMBL7900809 | 0.80 | GAA (0.40) | ELANEMEN1KMT2AUSP2 | |
| SCHEMBL31158205 | 0.79 | MEN1 (0.51) | F2ELANECTSGPSEN1PSEN2 | |
| SCHEMBL28956425 | 0.78 | PSEN1 (0.46) | F2ELANECTSGPSEN1PSEN2 | |
| SCHEMBL1114372 | 0.77 | PSEN1 (0.44) | F2ELANECTSGPSEN1PSEN2 | |
| SCHEMBL10207129 | 0.77 | POLB (0.49) | ELANEMEN1KMT2AUSP2 | |
| SCHEMBL29695931 | 0.72 | MEN1 (0.44) | F2ELANEPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |