Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3728141 | 1.00 | GAA (0.40) | GAAALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL6822684 | 1.00 | GAA (0.40) | GAAALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL9235945 | 1.00 | GAA (0.40) | GAAALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL10207129 | 0.88 | POLB (0.49) | GAAALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL3706217 | 0.81 | NR1H2 (0.42) | KMT2AMEN1USP2TSHR | |
| SCHEMBL894292 | 0.81 | NR1H2 (0.42) | KMT2AMEN1USP2TSHR | |
| SCHEMBL894291 | 0.81 | NR1H2 (0.42) | KMT2AMEN1USP2TSHR | |
| SCHEMBL28906947 | 0.80 | L3MBTL1 (0.42) | GAAALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL14897525 | 0.78 | RAB9A (0.40) | GAAALDH1A1POLBTSHR | |
| SCHEMBL13681382 | 0.77 | ALDH1A1 (0.41) | ALDH1A1CYP2C9CYP2C19KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6319702-B1 | NUCLEOTIDE SEQUENCS CODING AN ENZYMATIC POLYPEPTIDE AND CELL TARGETING COMPOUND; FOR USE IN TREATMENT OF CANCER | GLAXO WELLCOME, INC. | 2001-11-20 | — | — | US | disclosed |