Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.52 |
| ▸ | MMP1 | P03956 | 3/20 | 0.52 |
| ▸ | MMP9 | P14780 | 3/20 | 0.52 |
| ▸ | MMP3 | P08254 | 2/20 | 0.52 |
| ▸ | MMP7 | P09237 | 2/20 | 0.52 |
| ▸ | MMP13 | P45452 | 2/20 | 0.52 |
| ▸ | GRN | P28799 | 2/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.47 |
| ▸ | MMP12 | P39900 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.41 |
| ▸ | ACE | P12821 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869491 | 1.00 | MMP2 (0.52) | MMP2MMP1MMP9MMP3MMP7 | |
| SCHEMBL5869500 | 1.00 | MMP2 (0.52) | MMP2MMP1MMP9MMP3MMP7 | |
| SCHEMBL5870289 | 0.88 | MMP2 (0.58) | MMP2MMP1MMP9MMP3MMP7 | |
| SCHEMBL5870278 | 0.88 | MMP2 (0.58) | MMP2MMP1MMP9MMP3MMP7 | |
| SCHEMBL5870281 | 0.88 | MMP2 (0.58) | MMP2MMP1MMP9MMP3MMP7 | |
| SCHEMBL5869951 | 0.81 | MMP2 (0.53) | MMP2MMP1MMP9MMP3MMP7 | |
| SCHEMBL5869945 | 0.81 | MMP2 (0.53) | MMP2MMP1MMP9MMP3MMP7 | |
| SCHEMBL5869949 | 0.81 | MMP2 (0.53) | MMP2MMP1MMP9MMP3MMP7 | |
| SCHEMBL5869645 | 0.79 | ACE2 (0.54) | GRNSORT1ITGB1ITGA4ACE2 | |
| SCHEMBL5869640 | 0.79 | ACE2 (0.54) | GRNSORT1ITGB1ITGA4ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | MMP2 266/4885MMP1 1393/4885MMP9 1346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.