Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.58 |
| ▸ | MMP9 | P14780 | 10/20 | 0.58 |
| ▸ | MMP13 | P45452 | 5/20 | 0.58 |
| ▸ | MMP1 | P03956 | 4/20 | 0.58 |
| ▸ | MMP3 | P08254 | 4/20 | 0.58 |
| ▸ | MMP7 | P09237 | 3/20 | 0.58 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.53 |
| ▸ | MMP12 | P39900 | 3/20 | 0.53 |
| ▸ | MMP8 | P22894 | 3/20 | 0.53 |
| ▸ | MMP14 | P50281 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.49 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870289 | 1.00 | MMP2 (0.58) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL5870278 | 1.00 | MMP2 (0.58) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL5869491 | 0.88 | MMP2 (0.52) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL5869488 | 0.88 | MMP2 (0.52) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL5869500 | 0.88 | MMP2 (0.52) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL5869671 | 0.88 | MMP9 (0.56) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL5869667 | 0.88 | MMP9 (0.56) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL5869499 | 0.88 | MMP9 (0.56) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL5870434 | 0.85 | LARS1 (0.55) | GAACTSS | |
| SCHEMBL5870107 | 0.85 | LARS1 (0.55) | GAACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | MMP2 266/4885MMP9 1346/4885MMP13 1033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.