Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | ACE | P12821 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | APAF1 | O14727 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.60 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.60 |
| ▸ | ITGAL | P20701 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ECE1 | P42892 | 4/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8248646 | 1.00 | ALOX15 (0.63) | ALOX15ACEKDM4EMAPTAPAF1 | |
| SCHEMBL7222741 | 0.90 | ALOX15 (0.66) | ALOX15ACEKDM4EMAPTAPAF1 | |
| SCHEMBL19737124 | 0.86 | ACE (0.70) | ALOX15ACEKDM4EMAPTAPAF1 | |
| SCHEMBL15592745 | 0.86 | ACE (0.70) | ALOX15ACEKDM4EMAPTAPAF1 | |
| SCHEMBL1263833 | 0.86 | KDM4E (0.72) | ALOX15ACEKDM4EMAPTAPAF1 | |
| SCHEMBL1263822 | 0.86 | KDM4E (0.72) | ALOX15ACEKDM4EMAPTAPAF1 | |
| SCHEMBL16750046 | 0.86 | ACE (0.70) | ALOX15ACEKDM4EMAPTAPAF1 | |
| SCHEMBL29114797 | 0.85 | ACE (0.65) | ALOX15ACEKDM4EMAPTAPAF1 | |
| SCHEMBL8254531 | 0.85 | ACE (0.68) | ALOX15ACEKDM4EMAPTAPAF1 | |
| SCHEMBL5870457 | 0.85 | ACE (0.68) | ALOX15ACEKDM4EMAPTAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |