Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.54 |
| ▸ | CTSS | P25774 | 2/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | LAP3 | P28838 | 1/20 | 0.46 |
| ▸ | IL1RN | P18510 | 1/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 3/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421836 | 1.00 | CTSK (0.54) | CTSKCTSSCTSLLMNAL3MBTL1 | |
| SCHEMBL5870517 | 0.89 | AAK1 (0.46) | CTSKCTSLMMEACECPA1 | |
| SCHEMBL5870515 | 0.89 | AAK1 (0.46) | CTSKCTSLMMEACECPA1 | |
| SCHEMBL5870522 | 0.89 | AAK1 (0.46) | CTSKCTSLMMEACECPA1 | |
| SCHEMBL5870551 | 0.87 | LMNA (0.48) | CTSKCTSSCTSLLMNAL3MBTL1 | |
| SCHEMBL7535066 | 0.87 | LMNA (0.48) | CTSKCTSSCTSLLMNAL3MBTL1 | |
| SCHEMBL5869726 | 0.85 | FOLH1 (0.51) | CTSKCTSLACE | |
| SCHEMBL5870077 | 0.85 | CTSK (0.48) | CTSKCTSL | |
| SCHEMBL5869730 | 0.85 | FOLH1 (0.51) | CTSKCTSLACE | |
| SCHEMBL5870079 | 0.85 | CTSK (0.48) | CTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |