Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8248805 | 1.00 | FOLH1 (0.48) | FOLH1MMEALDH1A1ANPEPCYP2C19 | |
| SCHEMBL5869386 | 0.81 | MME (0.55) | FOLH1MMEALDH1A1ACETDP1 | |
| SCHEMBL5869343 | 0.81 | MME (0.55) | FOLH1MMEALDH1A1ACETDP1 | |
| SCHEMBL5869380 | 0.81 | MME (0.55) | FOLH1MMEALDH1A1ACETDP1 | |
| SCHEMBL5870042 | 0.81 | MME (0.44) | FOLH1MMELTA4HACE | |
| SCHEMBL8249013 | 0.81 | MME (0.44) | FOLH1MMELTA4HACE | |
| SCHEMBL8255233 | 0.76 | MMP3 (0.47) | MMEANPEPLTA4HACE | |
| SCHEMBL5869885 | 0.76 | MMP3 (0.47) | MMEANPEPLTA4HACE | |
| SCHEMBL5870172 | 0.75 | POLB (0.42) | MMEALDH1A1MAPK1TDP1 | |
| SCHEMBL8258150 | 0.75 | CYP2C19 (0.49) | ALDH1A1CYP2C19TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |