Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 3/20 | 0.47 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869885 | 1.00 | MMP3 (0.47) | MMP3MMEACEANPEPLTA4H | |
| SCHEMBL8249153 | 0.84 | MME (0.62) | MMP3MMEACEANPEPLTA4H | |
| SCHEMBL8248814 | 0.84 | MME (0.62) | MMP3MMEACEANPEPLTA4H | |
| SCHEMBL8248719 | 0.84 | MME (0.62) | MMP3MMEACEANPEPLTA4H | |
| SCHEMBL8248581 | 0.84 | MME (0.62) | MMP3MMEACEANPEPLTA4H | |
| SCHEMBL5869766 | 0.84 | MME (0.62) | MMP3MMEACEANPEPLTA4H | |
| SCHEMBL9180905 | 0.82 | ACE (0.52) | MMEACEMMP2MMP12MMP13 | |
| SCHEMBL4878546 | 0.79 | SIGMAR1 (0.51) | MMP3MMP2MMP12MMP13TSHR | |
| SCHEMBL4878542 | 0.79 | SIGMAR1 (0.51) | MMP3MMP2MMP12MMP13TSHR | |
| SCHEMBL4888131 | 0.79 | SIGMAR1 (0.51) | MMP3MMP2MMP12MMP13TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | MMP3 379/4885MME 11/4885ACE 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.