Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8254423 | 1.00 | POLB (0.42) | POLBAPEX1CTDSP1TDP1L3MBTL1 | |
| SCHEMBL5869880 | 0.78 | CYP2C19 (0.49) | POLBTDP1L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL8258150 | 0.78 | CYP2C19 (0.49) | POLBTDP1L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL22092483 | 0.76 | MIF (0.44) | POLBAPEX1CTDSP1TDP1L3MBTL1 | |
| SCHEMBL20088246 | 0.76 | CTSS (0.45) | POLBTDP1KMT2AALDH1A1NPC1 | |
| SCHEMBL5869820 | 0.75 | FOLH1 (0.48) | TDP1MMEALDH1A1MAPK1 | |
| SCHEMBL8248805 | 0.75 | FOLH1 (0.48) | TDP1MMEALDH1A1MAPK1 | |
| SCHEMBL18906025 | 0.73 | MIF (0.47) | POLBAPEX1CTDSP1TDP1L3MBTL1 | |
| SCHEMBL19143361 | 0.73 | MIF (0.47) | POLBAPEX1CTDSP1TDP1L3MBTL1 | |
| SCHEMBL5869885 | 0.73 | MMP3 (0.47) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |