Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 1/20 | 0.60 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.60 |
| ▸ | MME | P08473 | 4/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 2/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11516645 | 0.82 | ACE (0.60) | ACE | |
| SCHEMBL11803631 | 0.78 | GRN (0.53) | GRNSORT1MMELTA4HACE | |
| SCHEMBL28951535 | 0.77 | CTSK (0.55) | GRNSORT1MMELTA4H | |
| SCHEMBL28951532 | 0.77 | CTSK (0.55) | GRNSORT1MMELTA4H | |
| SCHEMBL11274358 | 0.77 | GRN (0.52) | GRNSORT1MMELTA4H | |
| SCHEMBL24668413 | 0.76 | ALDH1A1 (0.58) | GRNSORT1MMEACEACE2 | |
| SCHEMBL19181234 | 0.76 | MME (0.51) | GRNSORT1MMELTA4HACE | |
| SCHEMBL19181235 | 0.76 | MME (0.51) | GRNSORT1MMELTA4HACE | |
| SCHEMBL28703600 | 0.76 | NPSR1 (0.66) | GRNSORT1MMELTA4HNPSR1 | |
| SCHEMBL28703598 | 0.76 | NPSR1 (0.66) | GRNSORT1MMELTA4HNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |