Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 4/20 | 0.35 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870405 | 0.83 | CTSS (0.39) | CTSSCTSKCTSL | |
| SCHEMBL6651574 | 0.73 | SMN1; SMN2 (0.49) | SMN1; SMN2USP2CTSSCTSKTSHR | |
| SCHEMBL5870600 | 0.71 | CTSK (0.35) | CTSSCTSKPOLBCTSL | |
| SCHEMBL5870342 | 0.70 | CTSS (0.35) | SMN1; SMN2USP2CTSSCTSKTSHR | |
| SCHEMBL5870295 | 0.69 | ABHD6 (0.42) | RAB9AALDH1A1POLBCYP1A2CYP2C9 | |
| SCHEMBL4449255 | 0.69 | CTSK (0.46) | SMN1; SMN2USP2CTSSCTSKTSHR | |
| SCHEMBL5870424 | 0.68 | HDAC8 (0.41) | CTSSCTSKRAB9AALDH1A1POLB | |
| SCHEMBL19500285 | 0.60 | SMN1; SMN2 (0.56) | SMN1; SMN2USP2TSHRRECQLRAB9A | |
| SCHEMBL6063838 | 0.60 | CTSS (0.44) | CTSSCTSKTSHRALDH1A1CTSL | |
| SCHEMBL12206737 | 0.59 | TSHR (0.55) | SMN1; SMN2USP2TSHRRECQLRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132449-B2 | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LIMITED (GB) | 2006-11-07 | — | — | US | disclosed |