Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfadiazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.96 |
| ▸ | AURKA | O14965 | 1/20 | 0.96 |
| ▸ | DHFR | P00374 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 1/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | EDNRA | P25101 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfadiazine SCHEMBL27499602 | 1.00 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL10422849 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL24176 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL30080807 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL16860643 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL5870705 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL6141086 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL11611850 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL1486826 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL34517 | 0.96 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110642795-A | Preparation method for synthesizing nano sulfadiazine copper | 西安工业大学 | 2020-01-03 | — | — | CN | claimed |
| CN-1203229-A | Sulfadiazine copper and its preparing process and medicine thereof | WUHAN CENTRAL HOSPITAL ZHENGZH (CN) | 1998-12-30 | — | — | CN | claimed |
| CN-113289549-A | Spray freeze drying instrument capable of controlling particle size of nano powder | 西安工业大学 | 2021-08-24 | — | — | CN | disclosed |
| CN-110642795-A | Preparation method for synthesizing nano sulfadiazine copper | 西安工业大学 | 2020-01-03 | — | — | CN | disclosed |
| CN-110642795-A | Preparation method for synthesizing nano sulfadiazine copper | 西安工业大学 | 2020-01-03 | — | — | CN | disclosed |
| CN-110642795-A | Preparation method for synthesizing nano sulfadiazine copper | 西安工业大学 | 2020-01-03 | — | — | CN | disclosed |
| CN-102105501-B | Methods of producing cross-linked polysaccharide particles | RHODIA OPERATIONS | 2013-05-15 | — | — | CN | disclosed |
| CN-102105501-A | Methods of producing cross-linked polysaccharide particles | RHODIA | 2011-06-22 | — | — | CN | disclosed |
| US-7129021-B2 | Polymer system with switchable physical properties and its use in direct exposure printing plates | CREO SRL (BB) | 2006-10-31 | — | — | US | disclosed |
| EP-1108534-B1 | Polymer system and its use in direct exposure printing plates | CREO S R L (IN) | 2005-08-24 | — | — | EP | disclosed |
| US-20040081911-A1 | Polymer system with switchable physical properties and its use in direct exposure printing plates | CREO SRL (CA) | 2004-04-29 | — | — | US | disclosed |
| US-6632584-B1 | Having layer including polyacrylic acid and such as silver behenate; sharp switching between hydrophilic and hydrophobic properties; high tolerance to additives; low cost | CREO, INC. (CA) | 2003-10-14 | — | — | US | disclosed |
| US-20030162129-A1 | Polymer system with switchable physical properties and its use in direct exposure printing plates | CREO SRL | 2003-08-28 | — | — | US | disclosed |
| US-6503691-B1 | Crosslinkable polymer and metal salt of sulfamide derivatives | CREO SRL (BB) | 2003-01-07 | — | — | US | disclosed |
| EP-1108534-A1 | Polymer system and its use in direct exposure printing plates | Creo S.r.l. (IN) | 2001-06-20 | — | — | EP | disclosed |
| CN-1203229-A | Sulfadiazine copper and its preparing process and medicine thereof | WUHAN CENTRAL HOSPITAL ZHENGZH (CN) | 1998-12-30 | — | — | CN | disclosed |
| CN-1203229-A | Sulfadiazine copper and its preparing process and medicine thereof | WUHAN CENTRAL HOSPITAL ZHENGZH (CN) | 1998-12-30 | — | — | CN | disclosed |