Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfadiazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | AURKA | O14965 | 1/20 | 1.00 |
| ▸ | DHFR | P00374 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | EDNRA | P25101 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfadiazine SCHEMBL30080807 | 1.00 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL10422849 | 1.00 | LMNA (1.00) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL6141086 | 0.98 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL11611850 | 0.98 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL3728176 | 0.98 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL16860643 | 0.98 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL5870705 | 0.98 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL1486826 | 0.98 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL34517 | 0.98 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 | |
| Sulfadiazine SCHEMBL5870853 | 0.98 | LMNA (0.96) | LMNAAURKADHFRTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 35303 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146041-A1 | PANNEXIN-1 MODULATORS AND METHODS OF TREATING DISORDERS IN WHICH PANNEXIN-1 IS IMPLICATED | PANNEX THERAPEUTICS INC. (US) | 2026-05-28 | — | — | US | claimed |
| EP-4747256-A1 | PARP1 INHIBITOR COMPOUNDS | Duke Street Bio Limited (GB) | 2026-05-27 | — | — | EP | claimed |
| EP-4746972-A1 | DEUTERATED PARP1 INHIBITOR COMPOUNDS | Duke Street Bio Limited (GB) | 2026-05-27 | — | — | EP | claimed |
| CN-122076457-A | MnFe2O4Application of porous carbon matrix composite material as catalytic material to activate persulfate for degrading sulfonamides | — | 2026-05-26 | — | — | CN | claimed |
| CN-122094947-A | PARP1 inhibitor compounds | — | 2026-05-26 | — | — | CN | claimed |
| CN-122084567-A | Rapeseed quality detection method based on characteristic wavelength optimization and multimode fusion | — | 2026-05-26 | — | — | CN | claimed |
| CN-117169187-B | Preparation method of surface-enhanced Raman spectrum substrate for detecting residual of polysulfonamides | 江西农业大学 | 2026-05-22 | — | — | CN | claimed |
| US-20260138119-A1 | POLYMERS, FLUORINATED IONIC POLYMER NETWORKS, AND METHODS RELATED THERETO | THE UNIV OF NORTH CAROLINA AT CHAPEL HILL (US) | 2026-05-21 | — | — | US | claimed |
| CN-122059926-A | Heterocyclic degradation determinants for target protein degradation | C4医药公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122061341-A | High-strength breathable felt conveyor belt and production process | 广东华凯新材料有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-4221779-A | MALARIA | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1980-09-09 | — | — | US | claimed |
| US-4186184-A | Selective administration of drug with ocular therapeutic system | ALZA CORPORATION (US) | 1980-01-29 | — | — | US | claimed |
| US-4169763-A | OF A CORYNEBACTERIA RESISTANT TO ASPARTIC ACID ANALOGS AND SULFA DRUGS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1979-10-02 | — | — | US | claimed |
| US-4156067-A | BURN DRESSINGS, BODY IMPLANTS, MOLDINGS, PROTECTIVE COATINGS | TYNDALE PLAINS - HUNTER LTD. (US) | 1979-05-22 | — | — | US | claimed |
| US-4094976-A | ANTICOCCIDIAL CYCLICAMINO ETHANOLS AND ESTERS THEREOF | MERCK & CO., INC. (US) | 1978-06-13 | — | — | US | claimed |
| US-4087528-A | POTENTIATORS OF ANTIBACTERIAL SULFA DRUGS | ABBOTT LABORATORIES (US) | 1978-05-02 | — | — | US | claimed |
| US-4078058-A | Cerium sulfadiazine for treating burns | RESEARCH CORPORATION (US) | 1978-03-07 | — | — | US | claimed |
| US-4041160-A | N-METHYL-2-PYRROLIDONE, ANTICOCCIDIAL AGENTS | ABIC LTD. (IL) | 1977-08-09 | — | — | US | claimed |
| US-4016251-A | Vaginal drug dispensing device | ALZA CORPORATION (US) | 1977-04-05 | — | — | US | claimed |
| US-3960661-A | MUTANT BACILLUS SUBTILIS REQUIRING ADENINE FOR GROWTH | AJINOMOTO CO., INC. (JA) | 1976-06-01 | — | — | US | claimed |