SCHEMBL5872238

SCHEMBL5872238

C[C@H](N)C(c1ccccc1)c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 1/20 0.58
ADRA2C P18825 1/20 0.58
LMNA P02545 1/20 0.58
HIF1A Q16665 1/20 0.58
KDM4E B2RXH2 1/20 0.58
ALDH1A1 P00352 1/20 0.56
DPP4 P27487 2/20 0.52
F2 P00734 1/20 0.52
TAAR1 Q96RJ0 5/20 0.48
CYP2D6 P10635 1/20 0.44
AOC3 Q16853 1/20 0.43
MAOA P21397 1/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
SLC6A3 Q01959 1/20 0.42
SIGMAR1 Q99720 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1168170 1.00 ADRA2A (0.58) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL15667190 1.00 ADRA2A (0.58) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL13888777 0.89 LMNA (0.48) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL13870614 0.87 ADRB2 (0.56) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL14415605 0.84 ADRA2A (0.54) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL17504544 0.84 ADRA2A (0.54) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL14415604 0.84 ADRA2A (0.54) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL14415606 0.84 ADRA2A (0.54) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL14415607 0.84 ADRA2A (0.54) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL4151019 0.82 TAAR1 (0.64) TAAR1CYP2D6MAOASLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7126028-B1 Process for preparing chiral compounds THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS (GB) 2006-10-24 US disclosed
EP-1503754-A1 BETA-AGONIST COMPOUNDS COMPRISING NITRIC OXIDE DONOR GROUPS AND REACTIVE OXYGEN SPECIES SCAVENGER GROUPS AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISORDERS Yissum Research Development Company, of The Hebrew University of Jerusalem (IL) 2005-02-09 EP disclosed
WO-2003088961-A1 BETA-AGONIST COMPOUNDS COMPRISING NITRIC OXIDE DONOR GROUPS AND REACTIVE OXYGEN SPECIES SCAVENGER GROUPS AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISORDERS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2003-10-30 WO disclosed
EP-1135349-A1 PROCESS FOR PREPARING CHIRAL COMPOUNDS UNIVERSITY OF DURHAM (GB) 2001-09-26 EP disclosed
WO-2000034210-A1 PROCESS FOR PREPARING CHIRAL COMPOUNDS UNIVERSITY OF DURHAM (GB) 2000-06-15 WO disclosed