SCHEMBL5872372

SCHEMBL5872372

N#CCN1CCCCC1C(N)=O

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.35
POLB P06746 1/20 0.35
SPHK1 Q9NYA1 1/20 0.34
CTSB P07858 1/20 0.34
CTSS P25774 1/20 0.34
CTSK P43235 1/20 0.34
DPP7 Q9UHL4 4/20 0.33
SCN3A Q9NY46 1/20 0.33
DPP4 P27487 4/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
LMNA P02545 1/20 0.33
TSHR P16473 1/20 0.32
MAPK10 P53779 1/20 0.32
OPRM1 P35372 1/20 0.32
OPRL1 P41146 1/20 0.32
CD274 Q9NZQ7 1/20 0.31
DPP8 Q6V1X1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5872381 0.95 AR (0.39) ARPOLBSPHK1SCN3ADPP4
SCHEMBL2224084 0.79 CYP1A2 (0.40) LMNA
SCHEMBL2224080 0.79 CYP1A2 (0.40) LMNA
SCHEMBL14940944 0.79 POLB (0.39) ARPOLBSPHK1SCN3ADPP4
SCHEMBL23279350 0.77 SMN1; SMN2 (0.44) POLBSPHK1SCN3ALMNATSHR
SCHEMBL6808603 0.77 SMN1; SMN2 (0.44) POLBSPHK1SCN3ALMNATSHR
SCHEMBL6020379 0.75 ALDH1A1 (0.37) LMNA
SCHEMBL6020376 0.75 F2 (0.37) CTSBCTSSCTSKDPP4
SCHEMBL7024082 0.75 CNR2 (0.44) POLBSPHK1SCN3AMAOAMAOB
SCHEMBL6372054 0.75 POLB (0.39) POLBSPHK1CTSKSCN3AMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1372655-A4 CATHEPSIN CYSTEINE PROTEASE INHIBITORS MERCK FROSST CANADA INC (CA) 2005-10-12 EP claimed
EP-1372655-A2 CATHEPSIN CYSTEINE PROTEASE INHIBITORS Merck Frosst Canada & Co. (CA) 2004-01-02 EP claimed
WO-2002069901-A2 CATHEPSIN CYSTEINE PROTEASE INHIBITORS MERCK FROSST CANADA & CO. (CA) 2002-09-12 WO claimed
US-7012075-B2 Cathepsin cysteine protease inhibitors MERCK & CO., INC. (US) 2006-03-14 US disclosed
EP-1372655-A4 CATHEPSIN CYSTEINE PROTEASE INHIBITORS MERCK FROSST CANADA INC (CA) 2005-10-12 EP disclosed
EP-1372655-A2 CATHEPSIN CYSTEINE PROTEASE INHIBITORS Merck Frosst Canada & Co. (CA) 2004-01-02 EP disclosed
WO-2002069901-A2 CATHEPSIN CYSTEINE PROTEASE INHIBITORS MERCK FROSST CANADA & CO. (CA) 2002-09-12 WO disclosed