Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 10/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.48 |
| ▸ | MAPT | P10636 | 10/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 9/20 | 0.48 |
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | HPGD | P15428 | 7/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872518 | 0.74 | CRHR1 (0.58) | CRHR1RAB9AKDM4EMAPTKMT2A | |
| SCHEMBL5946531 | 0.74 | CRHR1 (0.52) | CRHR1RAB9AKDM4EMAPTKMT2A | |
| SCHEMBL5791018 | 0.70 | CRHR1 (0.60) | CRHR1RAB9AKDM4EMAPTKMT2A | |
| SCHEMBL3198742 | 0.68 | CRHR1 (0.54) | CRHR1RAB9AKDM4EMAPTKMT2A | |
| SCHEMBL5872511 | 0.65 | CRHR1 (0.61) | CRHR1RAB9AKDM4EMAPTKMT2A | |
| SCHEMBL31196726 | 0.65 | KDM4E (1.00) | RAB9AKDM4EMAPTKMT2ANPC1 | |
| SCHEMBL3189871 | 0.65 | CRHR1 (0.47) | CRHR1RAB9AKDM4EMAPTKMT2A | |
| SCHEMBL3188128 | 0.65 | MAPT (0.62) | CRHR1RAB9AKDM4EMAPTKMT2A | |
| SCHEMBL5600174 | 0.64 | CRHR1 (0.50) | CRHR1RAB9AKDM4EMAPTKMT2A | |
| SCHEMBL16934942 | 0.64 | KMT2A (0.72) | RAB9AKDM4EMAPTKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060270659-A1 | Pyrazolopyrimidines as CRF receptor antagonists | NEUROCRINE BIOSCIENCES, INC. (US) | 2006-11-30 | — | — | US | disclosed |
| EP-0880523-B1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES INC (US) | 2006-08-16 | — | — | EP | disclosed |
| US-7074797-B2 | Pyrazolopyrimidines as CRF receptor antagonists | NEUROCRINE BIOSCIENCES, INC. (US) | 2006-07-11 | — | — | US | disclosed |
| US-20040127483-A1 | Pyrazolopyrimidines as CRF receptor antagonists | NEUROCRINE BIOSCIENCES, INC. (US) | 2004-07-01 | — | — | US | disclosed |
| US-6664261-B2 | Endocrine, psychiatric and neurologic disorders from hypersecretion of corticotropin-releasing factor | NEUROCRINE BIOSCIENCES, INC. | 2003-12-16 | — | — | US | disclosed |
| US-20030125341-A1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. | 2003-07-03 | — | — | US | disclosed |
| EP-0880523-A1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997029109-A1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127483-A1 | Pyrazolopyrimidines as CRF receptor antagonists | CRHR1, CRHR2, CRH | CRHR1 1/4885RAB9A 2229/4885KDM4E 2814/4885 |
| US-20060270659-A1 | Pyrazolopyrimidines as CRF receptor antagonists | HTR5A, OPRL1, CRHR1 | CRHR1 3/4885RAB9A 1650/4885KDM4E 3366/4885 |
| US-20030125341-A1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | CRHR1, CRHR2, OPRL1 | CRHR1 1/4885RAB9A 3478/4885KDM4E 3509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.