Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ASAH1 | Q13510 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872635 | 1.00 | KMT2A (0.51) | KMT2ASMN1; SMN2ASAH1MEN1DNMT3A | |
| SCHEMBL11174003 | 0.88 | KMT2A (0.49) | KMT2ASMN1; SMN2ASAH1MEN1DNMT3A | |
| SCHEMBL2292398 | 0.87 | NPC1 (0.50) | KMT2ASMN1; SMN2ASAH1MEN1DNMT3A | |
| SCHEMBL2292401 | 0.87 | NPC1 (0.50) | KMT2ASMN1; SMN2ASAH1MEN1DNMT3A | |
| SCHEMBL2292393 | 0.87 | NPC1 (0.50) | KMT2ASMN1; SMN2ASAH1MEN1DNMT3A | |
| SCHEMBL12420180 | 0.83 | SMN1; SMN2 (0.50) | KMT2ASMN1; SMN2ASAH1MEN1DNMT3A | |
| SCHEMBL31561667 | 0.83 | SMN1; SMN2 (0.53) | KMT2ASMN1; SMN2ASAH1MEN1DNMT3A | |
| SCHEMBL12380644 | 0.82 | ALDH1A1 (0.47) | KMT2ASMN1; SMN2ASAH1MEN1DNMT3A | |
| SCHEMBL9304918 | 0.80 | SMN1; SMN2 (0.46) | KMT2ASMN1; SMN2ASAH1MEN1DNMT3A | |
| SCHEMBL9304930 | 0.80 | SMN1; SMN2 (0.46) | KMT2ASMN1; SMN2ASAH1MEN1DNMT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050171346-A1 | Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation | AVENTIS PHARMA S.A. (FR) | 2005-08-04 | — | — | US | claimed |
| US-7034022-B2 | Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation | AVENTIS PHARMA S. A. (FR) | 2006-04-25 | — | — | US | disclosed |
| US-20050171346-A1 | Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation | AVENTIS PHARMA S.A. (FR) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171346-A1 | Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation | HEXD, CDK5, CHUK | KMT2A 3045/4885SMN1; SMN2 3079/4885ASAH1 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.