SCHEMBL587268

SCHEMBL587268

COc1cccc(CC=O)c1N

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATP4A P20648 2/20 0.48
ATP4B P51164 2/20 0.48
ALDH1A1 P00352 4/20 0.42
IDO1 P14902 3/20 0.42
TAAR1 Q96RJ0 1/20 0.42
CHRM2 P08172 1/20 0.41
CHRM1 P11229 1/20 0.41
CHRM3 P20309 1/20 0.41
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
TLR2 O60603 1/20 0.40
ERN1 O75460 1/20 0.40
TLR1 Q15399 1/20 0.40
TLR6 Q9Y2C9 1/20 0.40
ADRA2B P18089 1/20 0.39
PTGS1 P23219 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CA12 O43570 2/20 0.38
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5829892 0.81 IDO1 (0.47) ATP4AATP4BALDH1A1IDO1TAAR1
SCHEMBL29957820 0.81 ALDH1A1 (0.54) ALDH1A1IDO1TAAR1CHRM2CHRM1
SCHEMBL249539 0.81 ALDH1A1 (0.54) ALDH1A1IDO1TAAR1CHRM2CHRM1
SCHEMBL5205282 0.80 CA12 (0.49) ALDH1A1GAACA12CA1CA2
SCHEMBL1353991 0.79 IDO1 (0.48) ATP4AATP4BALDH1A1IDO1TAAR1
SCHEMBL12884720 0.79 IDO1 (0.43) ATP4AATP4BALDH1A1IDO1TAAR1
SCHEMBL2477378 0.79 TLR2 (0.56) ALDH1A1IDO1GAAMAPTTLR2
SCHEMBL26654610 0.79 ALDH1A1 (0.42) ALDH1A1IDO1TAAR1CHRM2CHRM1
SCHEMBL16794991 0.79 HTR2A (0.45) ALDH1A1IDO1TAAR1CHRM2CHRM1
SCHEMBL578043 0.77 ALDH1A1 (0.41) ALDH1A1GAAMAPTKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2417111-A1 SUBSTITUTED 1-ALKYLCINNOLIN-4(1H)-ONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION OF SAME SANOFI (FR) 2012-02-15 EP disclosed
EP-2313376-A2 SUBSTITUTED 1-BENZYL-CINNOLIN-4(1H)-ONE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF Sanofi-Aventis (FR) 2011-04-27 EP disclosed
WO-2010116084-A1 SUBSTITUTED 1-ALKYLCINNOLIN-4(1H)-ONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION OF SAME SANOFI-AVENTIS (FR) 2010-10-14 WO disclosed
WO-2010004215-A2 SUBSTITUTED 1-BENZYL-CINNOLIN-4(1H)-ONE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2010-01-14 WO disclosed
EP-1899307-A1 8-ALK0XY-4-METHYL-3, 4-DIHYDR0-QUINAZ0LIN-2-YL AMINES AND THEIR USE AS 5-HT5A RECEPTOR LIGANDS F. Hoffmann-Roche AG (CH) 2008-03-19 EP disclosed
WO-2007000393-A1 8-ALK0XY-4-METHYL-3 , 4-DIHYDR0-QUINAZ0LIN-2-YL AMINES AND THEIR USE AS 5-HT5A RECEPTOR LIGANDS F. HOFFMANN-LA ROCHE AG (CH) 2007-01-04 WO disclosed