Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
| ▸ | NAAA | Q02083 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872892 | 0.85 | MAP2K2 (0.41) | TSHRHTTSMN1; SMN2KMT2AHCRTR1 | |
| SCHEMBL5872819 | 0.83 | LMNA (0.48) | NAAALMNATSHRHTTSMN1; SMN2 | |
| SCHEMBL5872805 | 0.81 | ALDH1A1 (0.51) | LMNATSHRSMN1; SMN2KMT2A | |
| SCHEMBL5872955 | 0.81 | MAP2K1 (0.42) | HCAR2KMT2AIDO1MAP2K2MAP2K1 | |
| SCHEMBL5872799 | 0.80 | MAP2K1 (0.49) | KMT2AIDO1MAP2K2MAP2K1 | |
| SCHEMBL5872855 | 0.80 | MAP2K1 (0.42) | LMNAHTTSMN1; SMN2KMT2AIDO1 | |
| SCHEMBL5873116 | 0.80 | MAP2K1 (0.48) | HTTKMT2AIDO1MAP2K2MAP2K1 | |
| SCHEMBL5872839 | 0.79 | MAP2K1 (0.42) | KMT2AIDO1MAP2K2MAP2K1 | |
| SCHEMBL5872787 | 0.79 | MAP2K1 (0.42) | KMT2AHCRTR1HCRTR2IDO1MAP2K2 | |
| SCHEMBL5872944 | 0.79 | MAP2K1 (0.43) | KMT2AIDO1MAP2K2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001905-B2 | Substituted diarylamines as MEK inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-02-21 | — | — | US | disclosed |
| US-20030225076-A1 | 5-Amide substituted diarylamines as mex inhibitors | BIWERSI CATHLIN (US) | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225076-A1 | 5-Amide substituted diarylamines as mex inhibitors | NRAS, MAPK6, MAPK12 | HCAR2 670/4885NAAA 2176/4885LMNA 2398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.