Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.59 |
| ▸ | CDK4 | P11802 | 6/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.59 |
| ▸ | CCND1 | P24385 | 6/20 | 0.59 |
| ▸ | CCND3 | P30281 | 6/20 | 0.59 |
| ▸ | KDR | P35968 | 5/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5771326 | 0.82 | MAP2K4 (0.47) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL5777277 | 0.79 | KDM4E (0.63) | CDK2FGFR1KDM4EALDH1A1GLA | |
| SCHEMBL5776631 | 0.78 | IDO1 (0.50) | CDK2FGFR1KDM4EALDH1A1GAA | |
| SCHEMBL5247470 | 0.74 | CDK2 (1.00) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL5873036 | 0.74 | IDO1 (0.43) | CDK2FGFR1KDM4EALDH1A1GAA | |
| SCHEMBL5873029 | 0.74 | ITK (0.43) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL5250998 | 0.73 | CDK2 (1.00) | CDK2CDK4CCNA2CCND1CCND3 | |
| SCHEMBL5873219 | 0.73 | NAMPT (0.38) | KDM4EALDH1A1GAAHPGDITK | |
| SCHEMBL5872968 | 0.73 | IDO1 (0.68) | KDM4EALDH1A1GAAHPGDCLK2 | |
| SCHEMBL23496936 | 0.72 | IDO1 (0.56) | CDK2CDK4CCNA2CCND1CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050250823-A1 | Gyrase inhibitors | YAGER KRAIG | 2005-11-10 | — | — | US | disclosed |
| US-20050054697-A1 | Gyrase inhibitors | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054697-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | CDK2 214/4885CDK4 706/4885CCNA2 1362/4885 |
| US-20050250823-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | CDK2 214/4885CDK4 706/4885CCNA2 1362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.