Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 5/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 8/20 | 0.41 |
| ▸ | CDK4 | P11802 | 7/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.41 |
| ▸ | CCND1 | P24385 | 7/20 | 0.41 |
| ▸ | CCND3 | P30281 | 7/20 | 0.41 |
| ▸ | KDR | P35968 | 6/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772793 | 0.85 | JAK2 (0.43) | ITKJAK2CDK2CDK4CCNA2 | |
| SCHEMBL5872971 | 0.82 | KDM4E (0.44) | ITKJAK2CDK2FGFR1IDO1 | |
| SCHEMBL5769801 | 0.82 | ITK (0.48) | ITKJAK2IDO1KDM4EALDH1A1 | |
| SCHEMBL5773591 | 0.77 | JAK2 (0.47) | ITKJAK2CDK2CDK4CCNA2 | |
| SCHEMBL5774743 | 0.74 | IDO1 (0.43) | ITKJAK2KDRFGFR1IDO1 | |
| SCHEMBL5872967 | 0.74 | CDK2 (0.59) | ITKCDK2CDK4CCNA2CCND1 | |
| SCHEMBL5748633 | 0.71 | FGFR1 (0.53) | ITKJAK2FGFR1JAK3 | |
| SCHEMBL5771063 | 0.71 | LRRK2 (0.54) | ITKCDK2CDK4FGFR1KDM4E | |
| SCHEMBL5776631 | 0.70 | IDO1 (0.50) | ITKCDK2FGFR1IDO1KDM4E | |
| SCHEMBL5873030 | 0.69 | TDO2 (0.41) | JAK2KDRIDO1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050250823-A1 | Gyrase inhibitors | YAGER KRAIG | 2005-11-10 | — | — | US | disclosed |
| US-20050054697-A1 | Gyrase inhibitors | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054697-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | ITK 1969/4885JAK2 4304/4885CDK2 214/4885 |
| US-20050250823-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | ITK 1969/4885JAK2 4304/4885CDK2 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.