Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440239 | 0.83 | JAK2 (0.51) | JAK2TYK2ITGB1ITGA4ITGB7 | |
| SCHEMBL6614013 | 0.73 | JAK2 (0.39) | JAK2TYK2MAPTMEN1KMT2A | |
| SCHEMBL2955256 | 0.71 | MYC (0.49) | MEN1KMT2ALMNACYP1A2CYP3A4 | |
| SCHEMBL444748 | 0.71 | HDAC6 (0.55) | ITGB1ITGA4ITGB7MAPTTTR | |
| SCHEMBL121763 | 0.69 | TOP2A (0.55) | MAPTMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL2961898 | 0.69 | FTO (0.46) | MAPTALDH1A1TOP2A | |
| SCHEMBL442361 | 0.69 | DHODH (0.62) | JAK2TYK2ITGB1ITGA4ITGB7 | |
| SCHEMBL99535 | 0.69 | HPGD (0.64) | MAPTMEN1KMT2ALMNAUSP2 | |
| SCHEMBL29656832 | 0.69 | HPGD (0.64) | MAPTMEN1KMT2ALMNAUSP2 | |
| SCHEMBL460247 | 0.69 | TTR (0.69) | JAK2TYK2ITGB1ITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045539-B2 | Therapeutic benzoxazole compounds | ASTRAZENECA AB (SE) | 2006-05-16 | — | — | US | claimed |