Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.52 |
| ▸ | BACE1 | P56817 | 12/20 | 0.49 |
| ▸ | NCK1 | P16333 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 5/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28701986 | 0.83 | PLAU (0.50) | PLAUBACE1NCK1NCF1MCHR1 | |
| SCHEMBL5959990 | 0.83 | NMT1 (0.40) | PLAUBACE1 | |
| SCHEMBL10133371 | 0.79 | NPC1 (0.52) | — | |
| SCHEMBL27689981 | 0.77 | ALDH1A1 (0.50) | PLAU | |
| SCHEMBL7833601 | 0.76 | NPC1 (0.39) | MCHR1 | |
| SCHEMBL5873708 | 0.75 | PLAU (0.67) | PLAUBACE1NCK1NCF1MCHR1 | |
| SCHEMBL24164787 | 0.75 | MEN1 (0.60) | PLAU | |
| SCHEMBL12175387 | 0.74 | ALDH1A1 (0.45) | PLAU | |
| SCHEMBL4681143 | 0.73 | PLAU (0.57) | PLAUBACE1NCK1NCF1NOS2 | |
| SCHEMBL10133307 | 0.72 | NPC1 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084156-B2 | 2-Aminoquinoline compounds | MERCK & CO., INC. (US) | 2006-08-01 | — | — | US | disclosed |
| US-20050026915-A1 | 2-Aminoquinoline compounds | MERCK SHARP & DOHME CORP. | 2005-02-03 | — | — | US | disclosed |
| EP-1450801-A2 | 2-AMINOQUINOLINE COMPOUNDS | Merck & Co., Inc. (US) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003045313-A2 | 2-AMINOQUINOLINE COMPOUNDS | MERCK & CO. INC. (US) | 2003-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026915-A1 | 2-Aminoquinoline compounds | MCHR1, MCHR2, MC5R | PLAU 4780/4885BACE1 1078/4885NCK1 1783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.