Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872582 | 0.89 | CDK9 (0.40) | JAK3MAP3K11NTRK1CHEK1AURKA | |
| SCHEMBL6872584 | 0.89 | CDK9 (0.40) | JAK3MAP3K11NTRK1CHEK1AURKA | |
| SCHEMBL5873793 | 0.82 | JAK3 (0.39) | JAK3MAP3K11NTRK1CHEK1AURKA | |
| SCHEMBL5873796 | 0.82 | JAK3 (0.39) | JAK3MAP3K11NTRK1CHEK1AURKA | |
| SCHEMBL7728583 | 0.78 | JAK3 (0.36) | JAK3MAP3K11NTRK1CHEK1AURKA | |
| SCHEMBL5873915 | 0.78 | JAK3 (0.43) | JAK3MAP3K11NTRK1CHEK1AURKA | |
| SCHEMBL5873916 | 0.78 | JAK3 (0.43) | JAK3MAP3K11NTRK1CHEK1AURKA | |
| SCHEMBL5873838 | 0.77 | PTK2 (0.35) | JAK3MAP3K11METCDK9 | |
| SCHEMBL5873840 | 0.77 | PTK2 (0.35) | JAK3MAP3K11METCDK9 | |
| SCHEMBL5873883 | 0.76 | CCNT1 (0.35) | JAK3MAP3K11RETCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129253-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-31 | — | — | US | disclosed |
| US-20040191210-A1 | Compounds | GLENNON KIMBERLEY CAROLINE (US) | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040191210-A1 | Compounds | CDK1, AKT1, RPS6KA1 | JAK3 439/4885MAP3K11 75/4885NTRK1 1323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.