Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7726572 | 0.87 | AXL (0.32) | JAK3MAP3K11RET | |
| SCHEMBL5873793 | 0.82 | JAK3 (0.39) | JAK3MAP3K11NTRK1METCHEK1 | |
| SCHEMBL5873796 | 0.82 | JAK3 (0.39) | JAK3MAP3K11NTRK1METCHEK1 | |
| SCHEMBL6872584 | 0.79 | CDK9 (0.40) | JAK3MAP3K11NTRK1METCHEK1 | |
| SCHEMBL6872582 | 0.79 | CDK9 (0.40) | JAK3MAP3K11NTRK1METCHEK1 | |
| SCHEMBL5873916 | 0.79 | JAK3 (0.43) | JAK3MAP3K11NTRK1METCHEK1 | |
| SCHEMBL5873915 | 0.79 | JAK3 (0.43) | JAK3MAP3K11NTRK1METCHEK1 | |
| SCHEMBL5873862 | 0.78 | JAK3 (0.36) | JAK3MAP3K11NTRK1METCHEK1 | |
| SCHEMBL5430358 | 0.75 | ALDH1A1 (0.46) | JAK3MAP3K11NTRK1METCHEK1 | |
| SCHEMBL5430362 | 0.75 | ALDH1A1 (0.46) | JAK3MAP3K11NTRK1METCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165514-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-01-02 | — | — | EP | claimed |
| WO-2000056710-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-09-28 | — | — | WO | claimed |