Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | MGAM | O43451 | 2/20 | 0.58 |
| ▸ | DAO | P14920 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL8930504 | 1.00 | ALDH1A1 (0.65) | ALDH1A1MGAMDAOTSHRNAPRT | |
| Terephthalic Acid SCHEMBL27671578 | 0.96 | ALDH1A1 (0.65) | ALDH1A1MGAMDAOTSHRNAPRT | |
| Terephthalic Acid SCHEMBL27671577 | 0.96 | ALDH1A1 (0.65) | ALDH1A1MGAMDAOTSHRNAPRT | |
| Benzoic Acid SCHEMBL28624673 | 0.90 | NAPRT (0.61) | ALDH1A1MGAMDAOTSHRNAPRT | |
| Isophthalic Acid SCHEMBL28271214 | 0.90 | ALDH1A1 (0.57) | ALDH1A1MGAMPABPC1CYP3A4GPBAR1 | |
| Paraben SCHEMBL27516796 | 0.90 | ALDH1A1 (0.57) | ALDH1A1MGAMPABPC1GPBAR1GAA | |
| Aminobenzoic Acid SCHEMBL5874259 | 0.88 | ALDH1A1 (0.55) | ALDH1A1MGAMTSHRNAPRTPABPC1 | |
| Quinoline SCHEMBL372690 | 0.88 | ALDH1A1 (0.77) | ALDH1A1MGAMPABPC1CYP3A4CNR2 | |
| Quinoline SCHEMBL5874493 | 0.88 | ALDH1A1 (0.77) | ALDH1A1MGAMPABPC1CYP3A4CNR2 | |
| Quinoline SCHEMBL5283313 | 0.88 | ALDH1A1 (0.77) | ALDH1A1MGAMPABPC1CYP3A4CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |