Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.77 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MGAM | O43451 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL5283313 | 1.00 | ALDH1A1 (0.77) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL5874493 | 1.00 | ALDH1A1 (0.77) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL28197315 | 0.98 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL5875372 | 0.93 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL27473723 | 0.93 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL5272119 | 0.93 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL2201840 | 0.93 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL5875384 | 0.93 | ALDH1A1 (0.74) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL7208557 | 0.93 | ALDH1A1 (0.90) | ALDH1A1PABPC1MEN1KMT2AMGAM | |
| Quinoline SCHEMBL1783847 | 0.91 | ALDH1A1 (0.71) | ALDH1A1PABPC1MEN1KMT2AMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108947863-B | Preparation method of nucesin and intermediate thereof | 上海博志研新药物技术有限公司 | 2021-04-30 | — | — | CN | disclosed |
| CN-108383780-A | A kind of Pitavastatin（Ⅲ）Process for purification | 湖北荆江源制药股份有限公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-106727326-A | A kind of quinoxaline liposome and preparation method thereof | 河南牧翔动物药业有限公司 | 2017-05-31 | — | — | CN | disclosed |
| EP-2409964-B1 | Process for the preparation of carbonate derivatives | ABBOTT LAB (US) | 2016-01-27 | — | — | EP | disclosed |
| EP-1192139-B1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBOTT LAB (US) | 2012-04-18 | — | — | EP | disclosed |
| EP-2409964-A2 | Preparation of substituted carbonate and carbamate derivatives | Abbott Laboratories (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-2261212-A2 | Preparation of quinoline-substituted carbonate and carbamate derivatives | Abbott Laboratories (US) | 2010-12-15 | — | — | EP | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-7074932-B2 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBVIE INC. | 2006-07-11 | — | — | US | disclosed |
| US-20060128962-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ALLEN MICHAEL S | 2006-06-15 | — | — | US | disclosed |
| US-20030199696-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBVIE INC. | 2003-10-23 | — | — | US | disclosed |
| US-6579986-B2 | Metal-catalyzed coupling reactions for 6-o-substituted macrolide antibiotics | ABBOTT LABORATORIES | 2003-06-17 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| US-20020165390-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBVIE INC. | 2002-11-07 | — | — | US | disclosed |
| US-6417366-B2 | CHEMICAL INTERMEDIATE FOR MACROLACTONE ANTIBIOTIC | ABBOTT LABORATORIES | 2002-07-09 | — | — | US | disclosed |
| EP-1192139-A1 | PREPARATION OF QUINOLINE-SUBSTITUTED CARBONATE AND CARBAMATE DERIVATIVES | Abbott Laboratories (US) | 2002-04-03 | — | — | EP | disclosed |
| US-20020013468-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBVIE INC. | 2002-01-31 | — | — | US | disclosed |
| WO-2001000582-A1 | PREPARATION OF QUINOLINE-SUBSTITUTED CARBONATE AND CARBAMATE DERIVATIVES | ABBOTT LABORATORIES (US) | 2001-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128962-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | CA7, CA6, CA4 | ALDH1A1 4601/4885PABPC1 4494/4885MEN1 257/4885 |
| US-20030199696-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | CA7, CA6, CA4 | ALDH1A1 4601/4885PABPC1 4494/4885MEN1 257/4885 |
| US-20020165390-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | CA7, CA6, CA4 | ALDH1A1 4601/4885PABPC1 4494/4885MEN1 257/4885 |
| US-20020013468-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | CA7, CA6, CA4 | ALDH1A1 4601/4885PABPC1 4494/4885MEN1 257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.