Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.56 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PHF8 | Q9UPP1 | 6/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | KDM5C | P41229 | 4/20 | 0.48 |
| ▸ | KDM6B | O15054 | 2/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL27703264 | 1.00 | EGLN1 (0.56) | EGLN1LMNAALKBH5SUCNR1FFAR3 | |
| Succinic Acid SCHEMBL5874535 | 1.00 | EGLN1 (0.56) | EGLN1LMNAALKBH5SUCNR1FFAR3 | |
| Adipic Acid SCHEMBL5874822 | 0.88 | AKR1B1 (0.62) | LMNAAKR1B1PPARGPPARDPPARA | |
| Adipic Acid SCHEMBL5874828 | 0.88 | AKR1B1 (0.62) | LMNAAKR1B1PPARGPPARDPPARA | |
| Glutarate SCHEMBL5875264 | 0.88 | SLC22A6 (0.61) | LMNAFFAR3HDAC3HDAC1HDAC2 | |
| Glutarate SCHEMBL5875257 | 0.88 | SLC22A6 (0.61) | LMNAFFAR3HDAC3HDAC1HDAC2 | |
| Butyric Acid SCHEMBL5874704 | 0.88 | HDAC3 (0.72) | EGLN1LMNAALKBH5SUCNR1FFAR3 | |
| Butyric Acid SCHEMBL9351884 | 0.86 | HDAC3 (0.68) | EGLN1LMNAALKBH5SUCNR1FFAR3 | |
| Sebacic Acid SCHEMBL5875424 | 0.86 | GPR84 (0.64) | LMNAAKR1B1PPARGPPARDPPARA | |
| Azelaic Acid SCHEMBL4399605 | 0.86 | GPR84 (0.64) | LMNAAKR1B1PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |