Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Piperidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperidine SCHEMBL4439035 | 1.00 | ALDH1A1 (0.60) | ALDH1A1LMNACYP3A4GABRA1TSHR | |
| Sulfuric Acid SCHEMBL28813640 | 1.00 | ALDH1A1 (0.60) | ALDH1A1LMNACYP3A4GABRA1TSHR | |
| Azepane SCHEMBL29144238 | 1.00 | ALDH1A1 (0.60) | ALDH1A1LMNACYP3A4GABRA1TSHR | |
| Piperidine SCHEMBL18091131 | 0.97 | ALDH1A1 (0.56) | ALDH1A1LMNACYP3A4GABRA1TSHR | |
| Piperidine SCHEMBL27494539 | 0.97 | ALDH1A1 (0.56) | ALDH1A1LMNACYP3A4GABRA1TSHR | |
| Piperidine SCHEMBL29877069 | 0.97 | ALDH1A1 (0.56) | ALDH1A1LMNACYP3A4GABRA1TSHR | |
| Pyrrolidine SCHEMBL28642083 | 0.97 | ALDH1A1 (0.53) | ALDH1A1LMNACYP3A4GABRA1TSHR | |
| Pyrrolidine SCHEMBL3835047 | 0.97 | ALDH1A1 (0.53) | ALDH1A1LMNACYP3A4GABRA1TSHR | |
| Pyrrolidine SCHEMBL27815363 | 0.93 | ALDH1A1 (0.50) | ALDH1A1LMNACYP3A4GABRA1TSHR | |
| Sulfuric Acid SCHEMBL7741636 | 0.89 | CA5A (0.50) | ALDH1A1LMNACYP3A4GABRA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541664-B | A kind of method for synthesizing cyanoacrylate | 潍坊同业化学有限公司 | 2018-01-30 | — | — | CN | claimed |
| CN-105541664-A | Method for synthesizing cyanoacrylate | WEIFANG TONGYE CHEMICAL CO LTD | 2016-05-04 | — | — | CN | claimed |
| CN-105541664-B | A kind of method for synthesizing cyanoacrylate | 潍坊同业化学有限公司 | 2018-01-30 | — | — | CN | disclosed |
| CN-105017137-B | One kind prepares vitamin B by malic acid6Method | 新发药业有限公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-105541664-A | Method for synthesizing cyanoacrylate | WEIFANG TONGYE CHEMICAL CO LTD | 2016-05-04 | — | — | CN | disclosed |
| CN-105017137-A | Method of using malic acid to prepare vitamin B6 | XINFA PHARMACEUTICAL CO LTD | 2015-11-04 | — | — | CN | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| WO-2006018249-A1 | METHOD FOR THE PRODUCTION OF QUARTERNARY AMMONIA COMPOUNDS AT ATMOSPHERIC PRESSURE | BASF AKTIENGESELLSCHAFT (DE) | 2006-02-23 | — | — | WO | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |