Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.64 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.59 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.58 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.53 |
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.53 |
| ▸ | GABRP | O00591 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL5874910 | 1.00 | LMNA (0.64) | LMNAALKBH5SUCNR1EGLN1HDAC3 | |
| Succinic Acid SCHEMBL15402109 | 0.97 | LMNA (0.60) | LMNAALKBH5SUCNR1EGLN1HDAC3 | |
| Butyric Acid SCHEMBL27861544 | 0.87 | HDAC3 (0.81) | LMNAALKBH5SUCNR1EGLN1HDAC3 | |
| Butyric Acid SCHEMBL5874783 | 0.87 | — | — | |
| Adipic Acid SCHEMBL5874787 | 0.87 | LMNA (0.69) | LMNAHDAC11TSHRKMT2ATHRB | |
| Glutarate SCHEMBL5874605 | 0.87 | SLC22A6 (0.69) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| Adipic Acid SCHEMBL5874779 | 0.87 | LMNA (0.69) | LMNAHDAC11TSHRKMT2ATHRB | |
| Glutarate SCHEMBL5874599 | 0.87 | SLC22A6 (0.69) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL1085908 | 0.87 | HDAC3 (0.61) | LMNAALKBH5SUCNR1EGLN1HDAC3 | |
| Ethylamine SCHEMBL11190124 | 0.86 | LMNA (0.47) | LMNAALKBH5SUCNR1EGLN1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |