Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trichloroacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | BLM | P54132 | 3/20 | 0.33 |
| ▸ | ODC1 | P11926 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trichloroacetic Acid SCHEMBL8331735 | 0.88 | TSHR (0.67) | TSHRALDH1A1TP53GLRA1SLC6A9 | |
| Trichloroacetic Acid SCHEMBL8337130 | 0.84 | TSHR (0.71) | TSHRALDH1A1TP53OR51E2CYP1A2 | |
| Trichloroacetic Acid SCHEMBL9721918 | 0.84 | TSHR (0.71) | TSHRALDH1A1TP53OR51E2CYP1A2 | |
| Trichloroacetic Acid SCHEMBL3784104 | 0.79 | TSHR (0.62) | TSHRALDH1A1TP53GLRA1SLC6A9 | |
| Trichloroacetic Acid SCHEMBL5874964 | 0.79 | TSHR (0.62) | TSHRALDH1A1TP53GLRA1SLC6A9 | |
| Trichloroacetic Acid SCHEMBL9420645 | 0.79 | TSHR (0.62) | TSHRALDH1A1TP53 | |
| Monoethanolamine SCHEMBL1834156 | 0.77 | TSHR (0.67) | TSHRALDH1A1GLRA1SLC6A9OR51E2 | |
| Monoethanolamine SCHEMBL1263481 | 0.77 | — | — | |
| Trichloroacetic Acid SCHEMBL10745837 | 0.77 | — | — | |
| Trichloroacetic Acid SCHEMBL1331955 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |