Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GGT1 | P19440 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
| ▸ | ARG2 | P78540 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5051493 | 1.00 | TSHR (0.46) | TSHRMEN1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL1604360 | 0.82 | CHRM1 (0.39) | TSHRMEN1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL7532147 | 0.78 | TSHR (0.42) | TSHRMEN1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL5167196 | 0.78 | TSHR (0.42) | TSHRMEN1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL27665293 | 0.78 | ALDH1A1 (0.35) | TSHRMEN1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL202556 | 0.76 | ALDH1A1 (0.34) | TSHRMEN1ALDH1A1CYP1A2KMT2A | |
| Hydrochloric Acid SCHEMBL28842189 | 0.76 | ALDH1A1 (0.34) | TSHRMEN1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL22636108 | 0.76 | ALDH1A1 (0.34) | TSHRMEN1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL20854287 | 0.76 | ALDH1A1 (0.34) | TSHRMEN1ALDH1A1CYP1A2KMT2A | |
| Hydrochloric Acid SCHEMBL29880532 | 0.76 | ALDH1A1 (0.34) | TSHRMEN1ALDH1A1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8748375-B2 | Methods for affecting body composition using amylin agonists | AMYLIN PHARMACEUTICALS, LLC (US) | 2014-06-10 | — | — | US | disclosed |
| EP-1814590-B2 | TREATMENT OF OBESITY AND RELATED DISORDERS | AMYLIN PHARMACEUTICALS INC (US) | 2013-12-11 | — | — | EP | disclosed |
| US-8598120-B2 | Methods for treatment using amylin family peptides | AMYLIN PHARMACEUTICALS, LLC (US) | 2013-12-03 | — | — | US | disclosed |
| US-8394765-B2 | Methods of treating obesity with two different anti-obesity agents | AMYLIN PHARMACEUTICALS LLC (US) | 2013-03-12 | — | — | US | disclosed |
| US-20120196796-A1 | AMYLIN FAMILY PEPTIDES AND METHODS FOR MAKING AND USING THEM | AMYLIN PHARMACEUTICALS, INC. (US) | 2012-08-02 | — | — | US | disclosed |
| US-20120071401-A1 | AMYLIN AGONIST COMPOUNDS FOR ESTROGEN-DEFICIENT MAMMALS | Amylin Pharamaceuticals, Inc. (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120053118-A1 | METHODS FOR AFFECTING BODY COMPOSITION USING AMYLIN AGONISTS | AMYLIN PHARMACEUTICALS, INC. (US) | 2012-03-01 | — | — | US | disclosed |
| EP-2416797-A2 | AMYLIN AGONIST COMPOUNDS FOR ESTROGEN-DEFICIENT MAMMALS | Amylin Pharmaceuticals, Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| US-8114958-B2 | Therapy for metabolism disorders; obesity; diabetes; cardovascular disordrs; eating disorders; hypoglycemic agents; hypotensive agents; dyslipidemia; sleep disorders; respiraotry system disorders; osteoarthritis; insulin resistance | AMYLIN PHARMACEUTICALS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| EP-2286838-A2 | Treatment of obesity and related disorders | AMYLIN PHARMACEUTICALS, INC. (US) | 2011-02-23 | — | — | EP | disclosed |
| EP-1814590-B1 | TREATMENT OF OBESITY AND RELATED DISORDERS | AMYLIN PHARMACEUTICALS INC (US) | 2009-04-08 | — | — | EP | disclosed |
| US-20080274952-A1 | Amylin Family Peptides And Methods For Making And Using Them | AMYLIN PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | US | disclosed |
| US-20080207512-A1 | Methods for Treating Obesity and Obesity Related and Disorders | AMYLIN PHARMACEUTICALS, INC. (US) | 2008-08-28 | — | — | US | disclosed |
| EP-1954313-A1 | TREATMENT OF OBESITY AND RELATED DISORDERS | Amylin Pharmaceuticals, Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1814590-A2 | TREATMENT OF OBESITY AND RELATED DISORDERS | Amylin Pharmaceuticals, Inc. (US) | 2007-08-08 | — | — | EP | disclosed |
| WO-2007055743-A2 | TREATMENT OF OBESITY AND RELATED DISORDERS | AMYLIN PHARMACEUTICALS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007055728-A1 | TREATMENT OF OBESITY AND RELATED DISORDERS | AMYLIN PHARMACEUTICALS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| EP-1716172-A1 | AMYLIN FAMILY PEPTIDES AND METHODS FOR MAKING AND USING THEM | Amylin Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2006083254-A1 | AMYLIN FAMILY PEPTIDES AND METHODS FOR MAKING AND USING THEM | AMYLIN PHARMACEUTICALS, INC. (US) | 2006-08-10 | — | — | WO | disclosed |
| WO-2006052608-A2 | TREATMENT OF OBESITY AND RELATED DISORDERS | AMYLIN PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071401-A1 | AMYLIN AGONIST COMPOUNDS FOR ESTROGEN-DEFICIENT MAMMALS | BDNF, ESR1, CYP19A1 | TSHR 1402/4885MEN1 505/4885ALDH1A1 3219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.