Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877668 | 1.00 | KDM4E (0.47) | KDM4EMAPK1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL7487486 | 0.90 | MEN1 (0.47) | KDM4EMAPK1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL7487482 | 0.90 | MEN1 (0.47) | KDM4EMAPK1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL5877029 | 0.89 | TUBB4A (0.51) | KDM4EMAPK1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL5877035 | 0.89 | TUBB4A (0.51) | KDM4EMAPK1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL5877289 | 0.88 | KDM4E (0.59) | KDM4EMAPK1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL5877288 | 0.88 | KDM4E (0.59) | KDM4EMAPK1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL5878166 | 0.88 | KDM4E (0.45) | KDM4EMAPK1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL5878162 | 0.88 | KDM4E (0.45) | KDM4EMAPK1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL5877957 | 0.87 | ALDH1A1 (0.42) | KDM4EALDH1A1TP53SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |