Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586709 | 0.96 | TP53 (0.41) | DPP4DPP8DPP9DPP7TP53 | |
| SCHEMBL581326 | 0.96 | TP53 (0.41) | TP53ALDH1A1TDP1HTTSLC6A9 | |
| SCHEMBL587087 | 0.90 | KMT2A (0.39) | ALDH1A1NOTUMMEN1MAPTKMT2A | |
| SCHEMBL587099 | 0.88 | ALDH1A1 (0.34) | DPP4DPP8DPP9DPP7TP53 | |
| SCHEMBL587216 | 0.85 | KMT2A (0.41) | DPP4DPP8DPP9DPP7ALDH1A1 | |
| SCHEMBL582067 | 0.85 | CYP2C9 (0.41) | NOTUMMAPTKMT2A | |
| SCHEMBL580928 | 0.85 | CYP2C19 (0.39) | P2RX7NOTUMMAPTKMT2AHSD11B1 | |
| SCHEMBL587349 | 0.84 | MMP1 (0.41) | MMP1ADAM17NOTUM | |
| Hydrochloric Acid SCHEMBL580918 | 0.84 | DPP4 (0.34) | DPP4DPP8DPP9DPP7TP53 | |
| SCHEMBL581895 | 0.83 | NOTUM (0.33) | DPP4DPP8DPP9DPP7NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |