Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581784 | 0.95 | NOTUM (0.44) | SLC6A3SLC6A4SLC6A2NOTUM | |
| SCHEMBL587352 | 0.95 | SLC6A3 (0.44) | MMP1ADAM17SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL587433 | 0.88 | SMN1; SMN2 (0.44) | SLC6A3SLC6A4SLC6A2NOTUM | |
| SCHEMBL587515 | 0.88 | FFAR2 (0.39) | MMP1ADAM17SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL586674 | 0.88 | NOTUM (0.44) | NOTUM | |
| SCHEMBL587575 | 0.85 | SLC6A4 (0.43) | MMP1ADAM17SLC6A4 | |
| SCHEMBL582040 | 0.85 | ALDH1A1 (0.48) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL587629 | 0.85 | ALDH1A1 (0.34) | MMP1ADAM17SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL587829 | 0.84 | DPP4 (0.38) | MMP1ADAM17NOTUM | |
| SCHEMBL582155 | 0.84 | RIPK1 (0.47) | SLC6A3SLC6A4SLC6A2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |