Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5878612 | 1.00 | NOS3 (0.41) | NOS3NOS1NOS2HTR2AMAP4K4 | |
| SCHEMBL7067558 | 0.79 | HTR2A (0.37) | HTR2ACHRNB2CHRNA4 | |
| SCHEMBL1506350 | 0.78 | CHRNB2 (0.52) | NOS3NOS1NOS2HTR2AMAP4K4 | |
| SCHEMBL1506348 | 0.78 | CHRNB2 (0.52) | NOS3NOS1NOS2HTR2AMAP4K4 | |
| SCHEMBL5198006 | 0.77 | CHRNB2 (0.39) | HTR2ACHRNB2CHRNA4 | |
| SCHEMBL5198003 | 0.77 | CHRNB2 (0.39) | HTR2ACHRNB2CHRNA4 | |
| SCHEMBL7529713 | 0.73 | CHRNB2 (0.41) | HTR2AMAP4K4CHRNB2CHRNA4 | |
| SCHEMBL6453858 | 0.73 | CHRNB2 (0.38) | HTR2ACHRNB2CHRNA4 | |
| SCHEMBL6453851 | 0.73 | CHRNB2 (0.38) | HTR2ACHRNB2CHRNA4 | |
| SCHEMBL4242134 | 0.72 | CHRNB2 (0.58) | MAP4K4CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006511482-A | — | — | 2006-04-06 | — | — | JP | claimed |
| EP-1556352-A1 | COMPOUNDS CAPABLE OF ACTIVATING CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2005-07-27 | — | — | EP | claimed |
| WO-2004031151-A1 | COMPOUNDS CAPABLE OF ACTIVATING CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2004-04-15 | — | — | WO | claimed |
| EP-1086082-B9 | ARYLSUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS | TARGACEPT INC (US) | 2005-03-02 | — | — | EP | disclosed |
| EP-1086082-B1 | ARYLSUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS | TARGACEPT INC (US) | 2004-08-18 | — | — | EP | disclosed |
| EP-1086082-A1 | ARYLSUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS | R.J. REYNOLDS TOBACCO COMPANY (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999065876-A1 | ARYL SUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS | R.J. REYNOLDS TOBACCO COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |