Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MASP2 | O00187 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422410 | 0.82 | HTR2A (0.37) | HTR2ACHRNB2CHRNA4CTSC | |
| SCHEMBL4422413 | 0.82 | HTR2A (0.37) | HTR2ACHRNB2CHRNA4CTSC | |
| SCHEMBL5878612 | 0.79 | NOS3 (0.41) | HTR2ACHRNB2CHRNA4 | |
| SCHEMBL5878615 | 0.79 | NOS3 (0.41) | HTR2ACHRNB2CHRNA4 | |
| SCHEMBL5198006 | 0.77 | CHRNB2 (0.39) | HTR2ACHRNB2CHRNA4 | |
| SCHEMBL5198003 | 0.77 | CHRNB2 (0.39) | HTR2ACHRNB2CHRNA4 | |
| SCHEMBL620193 | 0.74 | CHRNB2 (0.56) | HTR2AMASP2CHRNB2CHRNA4 | |
| SCHEMBL620192 | 0.74 | CHRNB2 (0.56) | HTR2AMASP2CHRNB2CHRNA4 | |
| SCHEMBL5199052 | 0.73 | CHRNB2 (0.60) | HTR2ACHRNB2CHRNA4 | |
| SCHEMBL3024293 | 0.73 | CHRNB2 (0.60) | HTR2ACHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317267-A2 | COMPOSITIONS CONTAINING DIACYLTARTARIC SALTS OF (E)-METANICOTINE | Targacept, Inc. (US) | 2003-06-11 | — | — | EP | disclosed |
| EP-1311265-A2 | PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS | Targacept, Inc. (US) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002005801-A2 | COMPOSITIONS CONTAINING DIACYLTARTARIC SALTS OF (E)-METANICOTINE | TARGACEPT, INC. (US) | 2002-01-24 | — | — | WO | disclosed |
| WO-2002005798-A2 | PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS | TARGACEPT, INC. (US) | 2002-01-24 | — | — | WO | disclosed |