Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12156632 | 0.85 | AOC3 (0.59) | AOC3KDM4EL3MBTL1TAAR1MEN1 | |
| SCHEMBL20356794 | 0.85 | AOC3 (0.59) | AOC3KDM4ETAAR1MEN1KMT2A | |
| SCHEMBL16155381 | 0.85 | AOC3 (0.63) | AOC3KDM4EL3MBTL1TAAR1MEN1 | |
| SCHEMBL13995351 | 0.84 | AOC3 (0.59) | AOC3KDM4EL3MBTL1TAAR1MEN1 | |
| SCHEMBL11957707 | 0.82 | AOC3 (0.62) | AOC3KDM4EL3MBTL1TAAR1MEN1 | |
| SCHEMBL3273864 | 0.82 | AOC3 (0.62) | AOC3KDM4EL3MBTL1TAAR1MEN1 | |
| SCHEMBL10748280 | 0.82 | TAAR1 (0.62) | AOC3KDM4EL3MBTL1TAAR1MEN1 | |
| SCHEMBL18756873 | 0.81 | AOC3 (0.63) | AOC3KDM4EL3MBTL1TAAR1MEN1 | |
| SCHEMBL28794562 | 0.81 | AOC3 (0.63) | AOC3KDM4EL3MBTL1TAAR1MEN1 | |
| SCHEMBL9641990 | 0.81 | KDM4E (0.54) | AOC3KDM4EL3MBTL1TAAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119176757-A | Preparation method of mianserin hydrochloride intermediate and derivative thereof | 四川青木制药有限公司 | 2024-12-24 | — | — | CN | disclosed |
| CN-103588715-A | Synthetic method for 1-methyl-3-phenylpiperazine | TAICANG YUNTONG BIOCHEMICAL ENGINEERING CO LTD | 2014-02-19 | — | — | CN | disclosed |
| CN-102649779-A | Synthesis method for medicine intermediate 1-methyl-3-phenylpiperazine | SHANDONG LUYAO PHARMACEUTICAL CO LTD | 2012-08-29 | — | — | CN | disclosed |
| US-20100249144-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | INTERVET INTERNATIONAL B.V. (NL) | 2010-09-30 | — | — | US | disclosed |
| US-20100249144-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | INTERVET INTERNATIONAL B.V. (NL) | 2010-09-30 | — | — | US | disclosed |
| WO-2009005645-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
| EP-1136470-B1 | PROCESS FOR THE PREPARATION OF A PIPERAZINE DERIVATIVE | SUMITOMO CHEMICAL CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| WO-2007038669-A2 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2007-04-05 | — | — | WO | disclosed |
| US-7053114-B2 | Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | SUGEN, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-7041826-B2 | reducing 4-benzyl-1-methyl-2-oxo-3-phenylpiperazine with lithium aluminum hydride to form 4-benzyl-1-methyl-3-phenylpiperazine; catalytic hydrogenation with palladium on carbon to form 1-methyl-3-phenylpiperazine; further conversion to the antidepressant, Mirtazapine; by-product inhibition | AUROBINDO PHARMA LTD. (IN) | 2006-05-09 | — | — | US | disclosed |
| WO-2004106309-A1 | A PROCESS FOR PREPARING 1-METHYL-3-PHENYLPIPERAZINE | AUROBINDO PHARMA LTD (IN) | 2004-12-09 | — | — | WO | disclosed |
| US-20040242879-A1 | Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate | AUROBINTO PHARMA LTD (IN) | 2004-12-02 | — | — | US | disclosed |
| US-6797725-B2 | SUCH AS 4-METHYL-5-(2-OXO-1,2-DIHYDROINDOL-3-YLILDENEMETHYL)-1H-PYRROLE-2-CARBOXYLIC ACID FOR PREVENTION AND TREATMENT OF PROTEIN KINASE RELATED CELLULAR DISORDERS; ANTICANCER AGENTS | SUGEN, INC. | 2004-09-28 | — | — | US | disclosed |
| US-20040186161-A1 | Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | SUGEN, INC. | 2004-09-23 | — | — | US | disclosed |
| US-20030100555-A1 | Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | SUGEN. INC. | 2003-05-29 | — | — | US | disclosed |
| WO-2002081466-A1 | PRODRUGS OF 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES | SUGEN, INC. (US) | 2002-10-17 | — | — | WO | disclosed |
| US-4254031-A | Synthesis for the preparation of tetracyclic compounds | AKZONA INCORPORATED (US) | 1981-03-03 | — | — | US | disclosed |
| US-4217452-A | Synthesis for the preparation of tetracyclic compounds | AKZONA INCORPORATED (US) | 1980-08-12 | — | — | US | disclosed |
| US-4025513-A | Synthesis for the preparation of tetracyclic compounds | AKZONA INCORPORATED (US) | 1977-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186161-A1 | Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | PLK2, CDK2, PDPK1 | AOC3 4583/4885KDM4E 1069/4885L3MBTL1 2701/4885 |
| US-20040242879-A1 | Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate | CYP4Z1, HTR5A, CYP3A5 | AOC3 1135/4885KDM4E 121/4885L3MBTL1 3458/4885 |
| US-20030100555-A1 | Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | PLK2, CDK2, PDPK1 | AOC3 4583/4885KDM4E 1069/4885L3MBTL1 2701/4885 |
| US-20100249144-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | CNR1, CNR2, GPR119 | AOC3 3432/4885KDM4E 2453/4885L3MBTL1 4560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.