Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.51 |
| ▸ | PRKCA | P17252 | 4/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | CDK4 | P11802 | 3/20 | 0.44 |
| ▸ | CCND1 | P24385 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879141 | 0.92 | CHEK1 (0.59) | CHEK1PRKCAADORA3ADORA2AADORA2B | |
| SCHEMBL5879158 | 0.87 | CHEK1 (0.71) | CHEK1PRKCAADORA3ADORA2AADORA2B | |
| SCHEMBL5879140 | 0.85 | CHEK1 (0.51) | CHEK1PRKCAADORA3ADORA2AADORA2B | |
| SCHEMBL5879196 | 0.84 | CHEK1 (0.50) | CHEK1PRKCAADORA3ADORA2AADORA2B | |
| SCHEMBL5879135 | 0.84 | CHEK1 (0.76) | CHEK1PRKCAADORA3ADORA2AADORA2B | |
| SCHEMBL5879307 | 0.83 | CHEK1 (0.49) | CHEK1PRKCAADORA3ADORA2AADORA2B | |
| SCHEMBL5879183 | 0.81 | ALDH1A1 (0.56) | CHEK1PRKCAADORA3ADORA2AADORA2B | |
| SCHEMBL5879218 | 0.81 | CHEK1 (0.50) | CHEK1PRKCAADORA3ADORA2AADORA2B | |
| SCHEMBL5879324 | 0.77 | ALDH1A1 (0.56) | CHEK1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL6201693 | 0.77 | MPO (0.58) | CHEK1PRKCAADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7151108-B2 | Anticarcinogenic, antiproliferative, and antitumor agents | LES LABORATORIES SERVIER (FR) | 2006-12-19 | — | — | US | disclosed |
| EP-1411057-B1 | [3,4-a:3,4-c]carbazole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-04-27 | — | — | EP | disclosed |
| EP-1411057-A1 | [3,4-a:3,4-c]carbazole derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2004-04-21 | — | — | EP | disclosed |