Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 12/20 | 0.53 |
| ▸ | RAB9A | P51151 | 12/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.53 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 6/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 4/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023990 | 0.74 | NPC1 (0.68) | SMN1; SMN2ALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL12153689 | 0.74 | NPC1 (0.77) | SMN1; SMN2ALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL5879506 | 0.74 | NPC1 (0.63) | SMN1; SMN2ALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL5897479 | 0.74 | PIM1 (0.71) | SMN1; SMN2ALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL5879554 | 0.72 | SMN1; SMN2 (0.68) | SMN1; SMN2ALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL15497747 | 0.72 | NPC1 (0.74) | SMN1; SMN2ALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL5029941 | 0.72 | RAB9A (0.60) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL29386825 | 0.72 | NPC1 (0.88) | SMN1; SMN2ALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL2178266 | 0.72 | NPC1 (0.88) | SMN1; SMN2ALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL3417301 | 0.71 | NPC1 (0.78) | SMN1; SMN2ALDH1A1HSD17B10HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125883-B1 | Integrin receptor ligands | ABBOTT GMBH & CO. KG (DE) | 2006-10-24 | — | — | US | disclosed |
| US-7105508-B1 | Integrin receptors antagonists | ABBOTT GMBH & CO. KG (DE) | 2006-09-12 | — | — | US | disclosed |
| EP-1202988-A2 | NOVEL INTEGRIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-05-08 | — | — | EP | disclosed |
| EP-1171435-A2 | PYRIMIDINE-2-ONE DERIVATIVES AS INTEGRIN RECEPTOR LIGANDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-01-16 | — | — | EP | disclosed |
| WO-2001010847-A2 | NOVEL INTEGRIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-15 | — | — | WO | disclosed |
| WO-2000061551-A2 | PYRIMIDINE-2-ONE DERIVATIVES AS INTEGRIN RECEPTOR LIGANDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-10-19 | — | — | WO | disclosed |